The first patient with malignant melanoma from Serbia went to Moscow to receive the newly approved mRNA cancer vaccine. Professor Dr. Vladimir Jakovljević from the Faculty of Medical Sciences in Kragujevac, who established cooperation with Professor Sergey Boljević there, confirmed this information to Nova.rs and pointed out that the patient will start therapy in the coming weeks, which lasts almost five months.
The Russian Ministry of Health approved a few days ago that the so-called personalized mRNA cancer vaccine can be freely applied to patients, and yesterday the news arrived that the first patient from Serbia, with malignant melanoma, has now gone to Moscow, so Serbia is among the first countries whose patient has been referred for this innovative therapy, Nova.rs reports.
According to Professor Vladimir Jakovljević from the Faculty of Medical Sciences in Kragujevac, the patient will receive the newly approved mRNA cancer vaccine in the coming weeks, which has generated great public interest, especially the part that is facing some form of cancer.
„Diagnosis of the health condition of the patient from Serbia began in Moscow today. The material of his tissue, from which the vaccine will be made, should be taken during the week. This is a personalized therapy that is made for each patient for that tumor. Specifically, this patient has malignant melanoma, and the vaccine being made for him is only for that type of tumor“, explains Dr. Jakovljević for Nova.rs.
The doctor adds that Russian scientists have worked hard in the previous period on attempts to personalize therapy for various types of cancer.
„When I encountered that therapy, it was said that it would be for the four most deadly tumors, which are lung carcinomas, kidney carcinomas, pancreatic carcinomas, and malignant melanoma, that famous, notorious evil mole that can cause huge problems, as it does. Russian scientists have worked a lot in the previous period on attempts to personalize therapy for various types of cancer. The first time I encountered that idea and the results of that work was last year when Alexander Gintsburg was a guest at our faculty in Kragujevac. In a conversation with us and our officials at the time, he presented the idea of starting work on it and that in some perspective they could establish cooperation with our competent institutions“, he states.
How it is received According to the interlocutor of Nova.rs, for this type of vaccine based on mRNA technology, diagnosis must first be performed.
„First, the patient’s diagnosis is done, and then the vaccine is made based on the tissue. The process of making the vaccine itself lasts from three weeks to a month. The vaccine is received over a period of five months in intervals of 10 doses every two weeks. This therapy stimulates the immune system to specifically react to that particular tumor“, he explains.
Who are the candidates The candidates for the Russian vaccine are, he explains, patients who have exhausted all previous therapy modalities.
„The criteria to be a candidate for this type of therapy are very strict and imply that you have passed all previous levels of treatment, including immunotherapy, which is now very popular and gives good results. If nothing else, it puts the cancer patient into chronicity, longer or shorter, which is one of the strategies. Practically, there is a complete change in the strategy for treating malignant diseases. As with some other things, the treatment of autoimmune diseases“.
The process of receiving the therapy itself is as follows:
„A biopsy of that tumor is taken, exposed to our bodily fluids, blood, serum, or plasma in laboratory conditions, and an antibody titer is created in our serum, using artificial intelligence methods, the number of which is many times higher than when waiting for the vaccine, as it was waited for, which can last for months. A higher concentration is achieved. They included the Lomonosov University, as one of the largest schools of mathematics in the world, which deals with artificial intelligence. And in about three weeks, they achieve such a level of antibodies. They create many antibodies that are then returned to the patient in 10 equal doses, every two weeks. The patient, therefore, must lie in a hospital in Russia for five months. We hope that he will be completely cured“, he states.
He emphasizes that the current focus is exclusively only on malignant melanoma, because permission for this has been obtained from the Ministry of Health of the Russian Federation.
„The treatment of all types of cancer has advanced considerably in the previous period. One of the strategies is to put cancer, where possible, into a chronic disease, such as diabetes, which is no less dangerous than cancer. The Russians give data that the success rate is between 95 and 100 percent, so we will see“, he concludes.
Cooperation with Prof. Sergey Boljević
When asked how it came about that Serbian patients are trying to be treated for cancer in Russia, he answers:
„Professor Sergey Boljević is the head of the Department of Pathology at Sechenov University in Moscow, the oldest Russian medical university. And I have been working in that department as a visiting professor for eight and a half years. Our cooperation has indeed been fruitful in the previous period, which can be seen by the number of papers in available databases and the number of Russian postgraduates who came to us. Which should be a source of pride for this country and the University of Kragujevac and the faculty, that Russian postgraduates come to our laboratory. We had fruitful cooperation, and as a long-time business partner, friend, and colleague whom he values, he included me in the Scientific Council that deals with the development of this technology. In short, the Russians immediately started working exclusively on patients for whom this is literally the last train, the last ticket for a possible cure“, states the Nova.rs interlocutor.
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Source: N1; Photo: Pixabay